Mitral Valve Degeneration With Mitral Regurgitation
Degenerative mitral valve prolapse without proper monitoring can cause severe mitral valve failure and occasionally lead to sudden death if the surgical correction is not performed on time. In most cases, mitral valve prolapse would cause mitral regurgitation which in a severe case would lead to left ventricle failure due to hemodynamic burden. The aim of this study is to develop a model to predict the degeneration behaviour of mitral valve which will aid the medical practitioner to estimate the mitral valve condition based on the available mitral regurgitation data by echocardiogram assessment. Minimal hemodynamic model has been adopted with modification to obtain mitral regurgitation severity information. The stress-strain behaviour of mitral leaflet has also been studied to model the degeneration of the mitral valve leaflet. The mitral valve degeneration was assessed by mitral valve leaflet elasticity properties while the severity of mitral regurgitation was measured by the volume of mitral regurgitation into the left atrium. It was found that the reduction of mitral valve leaflet elasticity would cause an increase of the mitral regurgitation volume into the left atrium. Mitral regurgitation severity was found to be less than that of left ventricle stroke volume when the mitral valve leaflet degenerates more than 90%.
Fellow at IJN-UTM Cardiovascular Engineering Centre
Dr. Kahar Osman is a Professor at the Faculty of Engineering, UTM, Malaysia. He is active in the Computational Fluid Mechanics Group and IJN-UTM Cardiovascular Engineering Center. His research interests include applications of computational fluid mechanics (CFD), fluid-structure interaction (FSI) and experimental techniques in the study of mechanical and cardiovascular systems, as well as analysis, designs, and optimizations of cardiovascular devices. He has been practicing CFD for more than 25 years. He started his work in flow modelling in the area of mechanical engineering and moved to biomedical engineering field since 10 years ago. He and his team have produced their own code for CFD modelling for bio-fluid. He is also currently working on stent development for different applications. He has published more than 120 articles in peer reviewed journals and proceedings. To date, he has led 15 projects as principal investigator and 26 projects as co-investigator. He has published more than 100 peer-reviewed academic journal articles in various level of publications.